- Thyroid hormone metabolism during inflammation and fasting
- Award date
- 9 April 2015
- Number of pages
- Document type
- PhD thesis
- Faculty of Medicine (AMC-UvA)
Pathophysiological circumstances such as illness and fasting affect the hypothalamus-pituitary-thyroid (HPT)-axis. The illness induced alterations, collectively known as the non-thyroidal illness syndrome (NTIS) are characterized by decreased serum T3 and T4 concentrations, increased serum rT3 concentrations and unaltered or inappropriately low serum TSH, indicating profoundly altered negative feedback in the pituitary and hypothalamus. Similar changes are observed during fasting. We recently showed that besides alterations in serum thyroid hormone (TH) concentrations, both illness and fasting are accompanied by tissue specific changes in deiodinases, which determine the availability of thyroid hormone (TH) in tissues. In this thesis we describe the experiments we have performed to investigate the underlying mechanisms of local changes in deiodinase activity; type 2 deiodinase activity in the hypothalamus during inflammation and type 3 deiodinase activity in the liver and white adipose tissue during fasting.
- Research conducted at: Universiteit van Amsterdam
If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library, or send a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible.