Most studies on pain focus on specific disorders, which makes it difficult to compare characteristics across different types
of pain symptoms. In this large population-based study, we examine the prevalence and comorbidity patterns among pain symptoms
across a wide range of anatomic sites (back, neck, head, abdomen, joints, chest, face, teeth, and "other") in relation to
anxious depression and a range of demographic, health, and lifestyle variables. Self-report data were collected in 11,787
adult participants of The Netherlands Twin Registry (mean age 44.5 years, 62% female), including twins and relatives of twins.
Headache and abdominal pain were strongly associated with female sex, whereas chest pain and toothache were not. Joint pain
strongly increased with age, whereas headache and abdominal pain decreased with age. Most other pain sites were only weakly
associated with age. A highly consistent pattern of comorbidity was observed: All pain symptoms were correlated with all other
pain symptoms, as well as with anxious depression. Frequent and widespread pain (ie, pain at multiple sites) was most strongly
associated with anxious depression. These observations reflect important differences between specific pain symptoms, suggesting
partly separate etiologies, but also highlight the importance of shared mechanisms underlying pain symptoms in general.