- The systemic right ventricle
- Award date
- 27 November 2014
- Number of pages
- Document type
- PhD thesis
- Faculty of Medicine (AMC-UvA)
In patients with a surgically corrected transposition of the great arteries or a congenitally corrected transposition of the great arteries, the right ventricle supports the systemic circulation. Although the right ventricle adjusts remarkably well to systemic pressures, long term complication seem inevitable. Most adult patients with a systemic right ventricle have decreased exercise intolerance and right ventricular dysfunction, and arrhythmias and clinical heart failure are common. Heart failure is the main cause of premature death in this population. This thesis focusses on the treatment and prevention of heart failure and exercise intolerance in patients with a systemic right ventricle. In a randomized clinical trail the efficacy of angiotensin II receptor blocker to prevent further deterioration of systemic right ventricular function. While valsartan did not approve right ventricular function, it attenuated further ventricular remodeling. Moreover, in a subgroup of patients with symptomatic heart failure, valsartan preserved right ventricular function, compared to placebo. In another randomized clinical trial we showed a beneficial effect of sports on the exercise capacity in patients with a systemic right ventricle. A separate, but related section of the thesis explores the epidemiology, in particular the prevalence and survival of adults with congenital heart disease in general.
- Research conducted at: Universiteit van Amsterdam
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