R.J.M. ten Berge
The combination of multifluorochrome flowcytometry and next generation sequencing used in this thesis shows that it is possible to characterize many aspects of the human anti-viral immune response.
Thus, this thesis paves the way for a better understanding of the phenotype, function and clonal relationships of virus-specific CD4+ and CD8+ T cells directed against many more proteins derived from many more viruses in a wide variety of tissues. The fact that an ever smaller sample can be used to perform such an analysis without loss of information, will allow for the study of virus-specific CD4+ and CD8+ T cells with extremely low frequencies and the analysis of anti-viral responses in small samples such as biopsies.
Research conducted at: Universiteit van Amsterdam
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