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Author
M. Sta
Title
Nervous immunity: A study on the role of complement system in neuronal degeneration and regeneration
Supervisors
F. Baas
Co-supervisors
K. Fluiter
Award date
12 November 2014
Number of pages
201
ISBN
9789462593602
Document type
PhD thesis
Faculty
Faculty of Medicine (AMC-UvA)
Abstract
This thesis describes research that shows that activation of the immune system is it not always beneficial. An activated immune system in the brain or in the peripheral nerves acts as a dual edged sword. A little activation is required for normal function, clearance and inhibiting disease progression. Chronic and massive activation of the immune system often results in excess damage and a more rapid disease progression and/or poorer outcome of the disease. Inhibition of the complement system can result in improved regeneration and delay of the disease progression, but the activation state of the complement system in each given stage of the disease should be carefully considered prior to inhibiting the terminal complement activation, membrane attack complex (MAC) formation.
Note
Research conducted at: Universiteit van Amsterdam
Permalink
http://hdl.handle.net/11245/1.432189
Downloads
  • Thesis (complete)

  • Front matter

  • Chapter 1: Complement activation in neurodegenerative disorders

  • Chapter 2: Macrophage depletion delays myelin clearance after peripheral nerve injury

  • Chapter 3: Gene expression in peripheral nerves after crush injury

  • Chapter 4: Functional and morphological characteristics of sciatic nerve degeneration and regeneration after crush injury in rats

  • Chapter 5: C6 deficiency does not alter intrinsic regeneration speed after peripheral nerve crush injury

  • Chapter 6: Functional recovery after transection-resuture injury of the sciatic nerve is not influenced by the terminal complement pathway in rats

  • Chapter 7: Innate and adaptive immunity in Amyotrophic lateral sclerosis: Evidence of complement activation

  • Chapter 8: Toll-like receptor signaling in amyotrophic lateral sclerosis spinal cord tissue

  • Chapter 9: General discussion: Nervous immunity is it always beneficial

  • Dutch summary / Nederlandse samenvatting

  • Back matter

  • Stellingen

Supplementary materials
  • English summary

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