The effect of high and low frequency cortical stimulation with a fixed or a poisson distributed interpulse interval on cortical excitability in rats

Buffel, I; Meurs, A.; Raedt, R.; De Herdt, V.; Decorte, L.; Bertier, L.; Delbeke, J.; Wadman, W.; Vonck, K.; Boon, P.

doi:https://doi.org/10.1142/S0129065714300058

Author: I Buffel
A. Meurs
R. Raedt
V. De Herdt
L. Decorte
L. Bertier
J. Delbeke
W. Wadman
K. Vonck
P. Boon
Year: 2014
Title: The effect of high and low frequency cortical stimulation with a fixed or a poisson distributed interpulse interval on cortical excitability in rats
Journal: International Journal of Neural Systems
Volume | Issue number: 24 | 1
Pages (from-to): 1430005
Number of pages: 10
Document type: Article
Faculty: Faculty of Science (FNWI)
Institute: Swammerdam Institute for Life Sciences (SILS)
Abstract: Neurostimulation is a promising treatment for refractory epilepsy. We studied the effect of cortical stimulation with different parameters in the rat motor cortex stimulation model. High intensity simulation (threshold for motor response--100 μA), high frequency (130 Hz) stimulation during 1 h decreased cortical excitability, irrespective of the interpulse interval used (fixed or Poisson distributed). Low intensity (10 μA) and/or low frequency (5 Hz) stimulation had no effect. Cortical stimulation appears promising for the treatment of neocortical epilepsy if frequency and intensity are high enough
URL: go to publisher's site
Language: English
Permalink: http://hdl.handle.net/11245/1.430284

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