- Modulation of fenretinide induced cell death in neuroblastoma
A.B.P. van Kuilenburg
- Award date
- 7 October 2014
- Number of pages
- Document type
- PhD thesis
- Faculty of Medicine (AMC-UvA)
- Neuroblastoma is a childhood tumor that, despite intensive therapy, has a poor prognosis especially in high risk patients. Therefore, new therapeutic options are needed to improve the outcome of these patients. The research described in this thesis attempts to unravel the apoptosis-inducing mechanism of fenretinide in neuroblastoma and, in order to increase its anti-tumor effects, we investigated possibilities for combination therapy.
- Research conducted at: Universiteit van Amsterdam
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