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Author
M. Lazzerini
R.L. Smith
Y. Budovskaya
Year
2013
Title
Developmental drift as a mechanism for ageing; lessons from nematodes
Journal
Biogerontology
Volume | Issue number
14 | 6
Pages (from-to)
693-701
Document type
Article
Faculty
Faculty of Science (FNWI)
Institute
Swammerdam Institute for Life Sciences (SILS)
Abstract
Aging is a universal biological process that afflicts every creature on this planet. To date, we have a very poor understanding of what actually causes this degeneration. A commonly held view is that aging is the result of damage accumulation over a lifetime. However, research has shown that aging is not only the result of wear and tear in the organism, but also of genetic programs involved in organismal development that go awry as selective pressure is released. This review focuses on Wnt signalling pathways and discusses how these genetic programs orchestrate changes in the organism that could cause aging.
URL
go to publisher's site
Language
English
Permalink
http://hdl.handle.net/11245/1.430086

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