- Targeting CD47-SIRPα interactions for potentiating therapeutic antibody-mediated tumor cell destruction by phagocytes
T.K. van den Berg
- Award date
- 2 July 2014
- Number of pages
- Document type
- PhD thesis
- Faculty of Medicine (AMC-UvA)
- The primary aim of the studies described in this thesis was to investigate the role of CD47-SIRPα interactions in therapeutic antibody-dependent tumor cell destruction by human phagocytes and also explore the killing mechanism(s) by which human phagocytes, and in particular human neutrophils, mediate therapeutic antibody-dependent cytotoxicity towards cancer cells.
- Research conducted at: Sanquin Research and Landsteiner Laboratory AMC
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