M.E. van Strien
The GFAP gene is alternatively spliced, and the canonical isoform GFAPα and an alternative spliced form GFAPδ represent the most abundant isoforms. In contrast to GFAPα, GFAPδ is assembly compromised and its expression levels are a crucial determinant of IF network assembly.
Our research has shown that a specialized GFAP network, induced by expression of an alternatively spliced isoform GFAPδ, modulates astrocyte motility, adhesion, and production of extracellular matrix proteins. Hence, modulation of the GFAP isoform signature modulates astrocyte function, which highlights the importance of a tight regulation of GFAP alternative splicing. In this respect, we unraveled that epigenetic modifications such as histone acetylation and transcriptional regulators, like Notch, are integral components in the control of GFAP isoform expression. Future research will focus on the mechanism of how GFAP, as part of the cytoskeleton, acts as a signaling platform in the cell to regulate vital cellular functions such as proliferation, motility, and adhesion of astrocytes.
If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library, or send a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible.