- Coagulation and fibrinolysis in tuberculosis, melioidosis and beyond
T. van der Poll
C. van 't Veer
- Award date
- 24 January 2014
- Number of pages
- Document type
- PhD thesis
- Faculty of Medicine (AMC-UvA)
The studies presented in this thesis significantly contribute to the current knowledge on the role of proteins involved in coagulation, anticoagulation and fibrinolysis during TB and melioidosis. We showed that during TB, although a chronic disease, the coagulation system becomes activated. The physiological significance of this activation, however, still is unclear and we failed to show a clear functional role for proteins involved in the PC system. With respect to melioidosis, we here demonstrated that some (components of) proteins involved in coagulation and fibrinolysis significantly contribute to the host defense against B. pseudomallei. This knowledge may add to further understanding of the pathophysiological processes during this severe septic disease and may serve as new targets for additional therapies.
- Research conducted at: Universiteit van Amsterdam
If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library, or send a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible.