- Cyclic causal discovery from continuous equilibrium data
- Conference on Uncertainty in Artificial Intelligence; 29 (Bellevue, Wash.)
- Book/source title
- Uncertainty in artificial intelligence: proceedings of the twenty-ninth conference (2013): July 12-14, 2013, Bellevue, Washington, United States
- Pages (from-to)
- AUAI Press
- Document type
- Conference contribution
- Faculty of Science (FNWI)
- Informatics Institute (IVI)
We propose a method for learning cycliccausal models from a combination of observational and interventional equilibrium data. Novel aspects of the proposed method are its ability to work with continuous data (without assuming linearity) and to deal with feedback loops. Within the context of biochemical reactions, we also propose a novel way of modeling interventions that modify the activity of compounds instead of their abundance. For computational reasons, we approximate the nonlinear causal mechanisms by (coupled) local linearizations, one for each experimental condition. We apply the method to reconstruct a cellular signaling network from the flow cytometry data measured by Sachs et al. (2005). We show that our method finds evidence in the data for feedback loops and that
it gives a more accurate quantitative description of the data at comparable model complexity.
If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library, or send a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible.