- Acquired TTP: ADAMTS13 meets the immune system
J.A. ten Brinke
- Award date
- 6 September 2013
- Number of pages
- Document type
- PhD thesis
- Faculty of Medicine (AMC-UvA)
- Autoantibodies directed against ADAMTS13 prohibit the processing of VWF multimers, initiating a rare and life-threatening disorder called acquired thrombotic thrombocytopenic purpura (TTP). At present it is not clear why previously healthy individuals develop anti-ADAMTS13 antibodies. The studies described in this thesis aim to increase our understanding of the molecular mechanisms involved in the generation of anti-ADAMTS13 antibodies in patients with acquired TTP.
- Research conducted at: Universiteit van Amsterdam
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