- Glycobiology in cardiometabolic homeostasis
- Award date
- 31 May 2013
- Number of pages
- Document type
- PhD thesis
- Faculty of Medicine (AMC-UvA)
The research presented in this thesis addresses several pathophysiological pathways in glucose and lipid metabolism, two major parameters of the cardiometabolic syndrome. Whereas the first part of the thesis deals with the cause of hypertriglyceridemia and novel treatment candidates targeting the cardiometabolic syndrome, the second part of this thesis explores the role of heparan sulfates in hyperglycaemia and hypertriglyceridemia. Moreover, using a translational approach we show that defects in heparan sulfate proteoglycan (HSPG) synthesis affects lipid and glucose metabolism.
- Research conducted at: Universiteit van Amsterdam
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