- Author
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J. van Es
- Title
- Adjustments in the diagnostic work-up, treatment and prognosis of pulmonary embolism
- Supervisors
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S. Middeldorp
P.W. Kamphuisen - Co-supervisors
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V.E.A. Gerdes
R.A. Douma - Award date
- 31 May 2013
- Number of pages
- 238
- ISBN
- 9789461917409
- Document type
- PhD thesis
- Faculty
- Faculty of Medicine (AMC-UvA)
- Abstract
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Pulmonary embolism is a potentially fatal condition, in which an embolus, usually a thrombus originating from one of the deep veins of the legs, blocks one or more pulmonary arteries. This leads to impaired blood flow through the lungs. Pulmonary embolism is the third most common cardiovascular disorder in Western society, affecting 1-2 per 1000 patients per year. The clinical presentation of patients with suspected acute pulmonary embolism varies from only mild symptoms to severe dyspnoea, pain on exertion, syncope, or even cardiogenic shock. This thesis focuses on the diagnostic work-up of pulmonary embolism, its treatment and prognosis. Strategies to improve diagnostic work-up and treatment are investigated. Further insight into prediction of the prognosis of pulmonary embolism is assessed by evaluating location of the clots and clot resolution as well as the duration of patients’ complaints and the quality of life of patients with pulmonary embolism.
- Note
- Research conducted at: Universiteit van Amsterdam
- Permalink
- http://hdl.handle.net/11245/1.394518
- Downloads
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Cover
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Title pages
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Table of contents
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Chapter 1: General introduction and outline of the thesis
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Chapter 2: Age-adjusted D-dimer safely and efficiently increases the proportion of patients in whom acute pulmonary embolism can be excluded, regardless the clinical decision rules used
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Chapter 3: Performance of four clinical decision rules in patients with malignancy and suspected pulmonary embolism
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Chapter 4: The accuracy of chest X-ray in combination with perfusion scanning as an alternative for CTPA in young patients with a high risk of pulmonary embolism
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Chapter 5: The accuracy of D-dimer testing in suspected pulmonary embolism varies with the Wells score
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Chapter 6: Combining Wells score with D-dimer results can reduce the need for CT-scanning in patients with suspected pulmonary embolism
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Chapter 7: Clinical impact of findings supporting an alternative diagnosis on computed tomography pulmonary angiography in patients with suspected pulmonary embolism
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Chapter 8: Urinary prothrombin fragment 1+2 in patients with venous thrombosis and myocardial infarction
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Chapter 9: How to prevent, treat, and overcome current clinical challenges of VTE
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Chapter 10: Acute pulmonary embolism. Part 2: Treatment
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Chapter 11: Clot resolution after 3 weeks of anticoagulant treatment of pulmonary embolism: Comparison of computed tomography and perfusion scintigraphy
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Chapter 12: Assessment of clot resolution following treatment of acute pulmonary embolism and its prognostic implications for recurrent venous thromboembolism
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Chapter 14: Risk profile and clinical outcome of symptomatic isolated subsegmental acute pulmonary embolism
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Chapter 15: Quality of life after pulmonary embolism as assessed with SF-36 and PEmb-QoL
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Chapter 16: Summary and future perspectives
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Nederlandse samenvatting
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Co-authors and affiliations
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Curriculum vitae
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List of publications and portfolio
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Dankwoord
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Stellingen
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