- The role of antigen in the development of B-cell chronic lymphocytic leukemia
C.J.M. van Noesel
- Award date
- 8 May 2013
- Number of pages
- Document type
- PhD thesis
- Faculty of Medicine (AMC-UvA)
- These studies strongly suggest that MALT-lymphomas and M-CLL in majority are highly selected for single extrinsic antigens and that these antigens can be both self-antigens and exo-antigens. Our finding that primary CLL cells are responsive to stimulation with their cognate antigen suggests that antigen-dependent BCR signaling may drive CLL expansion in vivo.
- Research conducted at: Universiteit van Amsterdam
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