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Author
H.G. Ruhé
Title
Dose-escalation in the picture : pharmacological and imaging studies in depression
Supervisors
A.H. Schene
Co-supervisors
J. Booij
Award date
5 November 2008
Number of pages
300
ISBN
9789090235592
Document type
PhD thesis
Faculty
Faculty of Medicine (AMC-UvA)
Note
Research conducted at: Universiteit van Amsterdam
Permalink
http://hdl.handle.net/11245/1.385714
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  • Thesis

  • Cover

  • Title pages

  • Contents

  • Chapter 1: General introduction and outline of the thesis

  • Chapter 2: Design and methods of the DELPHI-study

  • Chapter 3: Clinical use of the Hamilton Depression Rating Scale : is increased efficiency possible? A post hoc comparison of HDRS, Maier and Bech subscales, CGI and SCL-90 scores

  • Chapter 4: Dose-escalation for insufficient response to a standard dose of a selective serotonin reuptake inhibitor in major depressive disorder : a systematic review

  • Chapter 5: Switching antidepressants after a first selective serotonin reuptake inhibitor in major depressive disorder : a systematic review

  • Chapter 6: Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans : a meta-analysis of monoamine depletion studies

  • Chapter 7: Serotonin transporter binding with [123I]ß-CIT SPECT in major depressive disorder versus controls : effect of season and gender

  • Chapter 8: Serotonin transporter gene promoter polymorphisms modify the association between paroxetine serotonin transporter occupancy and clinical response in major depressive disorder

  • Chapter 9: Evidence why paroxetine dose-escalation is not effective in major depressive disorder : a randomized-controlled trial with assessment of serotonin transporter occupancy

  • Chapter 10: Successful pharmacological treatment of major depressive disorder attenuates amygdala activation to negative facial expressions : an fMRI study

  • Chapter 11: Effect of the selective serotonin reuptake inhibitor paroxetine on platelet function is modified by a SLC6A4 serotonin transporter polymorphism

  • Chapter 12: Summary, conclusions and general discussion

  • Chapter 13: Samenvatting en conclusies

  • Abbreviations

  • Color figures

  • Publications

  • Dankwoord

  • Curriculum vitae

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