Dose-escalation in the picture : pharmacological and imaging studies in depression

Ruhé, H.G.

Author: H.G. Ruhé
Title: Dose-escalation in the picture : pharmacological and imaging studies in depression
Supervisors: A.H. Schene
Co-supervisors: J. Booij
Award date: 5 November 2008
Number of pages: 300
ISBN: 9789090235592
Document type: PhD thesis
Faculty: Faculty of Medicine (AMC-UvA)
Note: Research conducted at: Universiteit van Amsterdam
Permalink: http://hdl.handle.net/11245/1.385714

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Thesis
Cover
Title pages
Contents
Chapter 1: General introduction and outline of the thesis
Chapter 2: Design and methods of the DELPHI-study
Chapter 3: Clinical use of the Hamilton Depression Rating Scale : is increased efficiency possible? A post hoc comparison of HDRS, Maier and Bech subscales, CGI and SCL-90 scores
Chapter 4: Dose-escalation for insufficient response to a standard dose of a selective serotonin reuptake inhibitor in major depressive disorder : a systematic review
Chapter 5: Switching antidepressants after a first selective serotonin reuptake inhibitor in major depressive disorder : a systematic review
Chapter 6: Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans : a meta-analysis of monoamine depletion studies
Chapter 7: Serotonin transporter binding with [123I]ß-CIT SPECT in major depressive disorder versus controls : effect of season and gender
Chapter 8: Serotonin transporter gene promoter polymorphisms modify the association between paroxetine serotonin transporter occupancy and clinical response in major depressive disorder
Chapter 9: Evidence why paroxetine dose-escalation is not effective in major depressive disorder : a randomized-controlled trial with assessment of serotonin transporter occupancy
Chapter 10: Successful pharmacological treatment of major depressive disorder attenuates amygdala activation to negative facial expressions : an fMRI study
Chapter 11: Effect of the selective serotonin reuptake inhibitor paroxetine on platelet function is modified by a SLC6A4 serotonin transporter polymorphism
Chapter 12: Summary, conclusions and general discussion
Chapter 13: Samenvatting en conclusies
Abbreviations
Color figures
Publications
Dankwoord
Curriculum vitae

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