- Author
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T.J. Hagenbeek
- Title
- The role of the phosphatase Pten in T cell development
- Supervisors
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H. Spits
- Award date
- 13 May 2008
- Number of pages
- 178
- Document type
- PhD thesis
- Faculty
- Faculty of Medicine (AMC-UvA)
- Note
- Research conducted at: Universiteit van Amsterdam
- Permalink
- http://hdl.handle.net/11245/1.385500
- Downloads
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Thesis
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Cover
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Titlepage
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Contents
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Chapter 1 General introduction: Normal and malignant T cell development: the role of PI3K and Notch
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Chapter 2 The loss of PTEN allows TCR αβ lineage thymocytes to bypass IL-7 and pre-TCR mediated signaling
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Chapter 3 Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking
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Chapter 4 T cell lymphomas in T cell-specific Pten-deficient mice originate in the thymus
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Chapter 5 TCR signaling is required for thymic exit of healthy and malignant Pten-deficient thymocytes
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Chapter 6 Malignant Pten-deficient thymocytes utilize independent PI3K- and Notch1-mediated signaling for survival and proliferation, and acquire activating NOTCH1 mutations upon loss of γc- and/or (pre-)TCR-mediated signaling
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Chapter 7 General discussion
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Summary
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Samenvatting
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List of publications
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Curriculum Vitae
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Dankwoord
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Stellingen
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