University of AmsterdamUniversity of AmsterdamUvA

  • Terms of use
  • Contact

UvA-DARE (Digital Academic Repository)

  • Home
  • Advanced Search
  • Browse
  • My selection

Search UvA-DARE

Author
T.J. Hagenbeek
Title
The role of the phosphatase Pten in T cell development
Supervisors
H. Spits
Award date
13 May 2008
Number of pages
178
Document type
PhD thesis
Faculty
Faculty of Medicine (AMC-UvA)
Note
Research conducted at: Universiteit van Amsterdam
Permalink
http://hdl.handle.net/11245/1.385500
Downloads
  • Thesis

  • Cover

  • Titlepage

  • Contents

  • Chapter 1 General introduction: Normal and malignant T cell development: the role of PI3K and Notch

  • Chapter 2 The loss of PTEN allows TCR αβ lineage thymocytes to bypass IL-7 and pre-TCR mediated signaling

  • Chapter 3 Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

  • Chapter 4 T cell lymphomas in T cell-specific Pten-deficient mice originate in the thymus

  • Chapter 5 TCR signaling is required for thymic exit of healthy and malignant Pten-deficient thymocytes

  • Chapter 6 Malignant Pten-deficient thymocytes utilize independent PI3K- and Notch1-mediated signaling for survival and proliferation, and acquire activating NOTCH1 mutations upon loss of γc- and/or (pre-)TCR-mediated signaling

  • Chapter 7 General discussion

  • Summary

  • Samenvatting

  • List of publications

  • Curriculum Vitae

  • Dankwoord

  • Stellingen

Disclaimer/Complaints regulations

If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library, or send a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible.

PrintPrint this pageShareShare via emailShare on facebookShare on linkedinShare on twitter
  • University library
  • About UvA-DARE
  • Disclaimer
Copyright UvA 2014