The role of the phosphatase Pten in T cell development

Hagenbeek, T.J.

Author: T.J. Hagenbeek
Title: The role of the phosphatase Pten in T cell development
Supervisors: H. Spits
Award date: 13 May 2008
Number of pages: 178
Document type: PhD thesis
Faculty: Faculty of Medicine (AMC-UvA)
Note: Research conducted at: Universiteit van Amsterdam
Permalink: http://hdl.handle.net/11245/1.385500

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Thesis
Cover
Titlepage
Contents
Chapter 1 General introduction: Normal and malignant T cell development: the role of PI3K and Notch
Chapter 2 The loss of PTEN allows TCR αβ lineage thymocytes to bypass IL-7 and pre-TCR mediated signaling
Chapter 3 Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking
Chapter 4 T cell lymphomas in T cell-specific Pten-deficient mice originate in the thymus
Chapter 5 TCR signaling is required for thymic exit of healthy and malignant Pten-deficient thymocytes
Chapter 6 Malignant Pten-deficient thymocytes utilize independent PI3K- and Notch1-mediated signaling for survival and proliferation, and acquire activating NOTCH1 mutations upon loss of γc- and/or (pre-)TCR-mediated signaling
Chapter 7 General discussion
Summary
Samenvatting
List of publications
Curriculum Vitae
Dankwoord
Stellingen

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