- Developing novel strategies for treating esophageal cancer: Dendritic cells immunotherapy, T cell responses and an exploration of the tumor microenvironment
- Award date
- 9 October 2007
- Number of pages
- Document type
- PhD thesis
- Faculty of Medicine (AMC-UvA)
The aim of this thesis is to investigate novel and more advantageous strategies to treat esophageal cancer, particularly focusing on dendritic cell (DC) immunotherapy. DC immunotherapy is an attractive strategy which could represent an alternative treatment approach for such an aggressive cancer. DC immunotherapy is still under development and in numerous aspects needs to be further optimized in preclinical studies. This thesis aimed at resolving a number of important difficulties in this field, in order to prepare for a phase I/II clinical trial.