S. van der Sluis
- Power in GWAS: lifting the curse of the clinical cut-off
- Molecular Psychiatry
- Pages (from-to)
- Document type
- Faculty of Social and Behavioural Sciences (FMG)
- Psychology Research Institute (PsyRes)
Although genome-wide association studies (GWAS), in general, facilitated important discovery of new biological knowledge about diseases,1, 2, 3 identified variants for psychiatric disorders explain little variation, and insight into the role of genes in highly heritable psychiatric traits remains poor.4, 5 Low statistical power is seen as the main reason for the failure to locate more variants, and has resulted in a call for larger samples. Our present study, however, shows that better use of (available) phenotypic information can also increase power considerably.
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