- Enantioselective organocatalytic thiol addition to alpha,beta-unsaturated alpha-amino acid derivatives
- Volume | Issue number
- 23 | 15
- Pages (from-to)
- Document type
- Faculty of Science (FNWI)
- Van 't Hoff Institute for Molecular Sciences (HIMS)
- A new class of Michael acceptors based on α,β-unsaturated amino acids has been prepared and applied in asymmetric organocatalysis.
With the use of thiourea derivatives of cinchona alkaloid-derived catalysts, efficient addition of thiols to the dehydroamino
acids occurred with formation of β-thiol functionalized α-amino acids in high yields, moderate diastereoselectivities and
ee values up to 95%.
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