C.S. van der Zwaluw
H. van der Vorst
- The Moderating Effect of Alcohol-Specific Parental Rule-Setting on the Relation between the Dopamine D2 Receptor Gene (DRD2), the Mu-Opioid Receptor Gene (OPRM1) and Alcohol Use in Young Adolescents
- Alcohol and Alcoholism
- Volume | Issue number
- 47 | 6
- Pages (from-to)
- Document type
- Faculty of Social and Behavioural Sciences (FMG)
- Psychology Research Institute (PsyRes)
Aims: The main aim of the study was to test the moderating effect of two genetic polymorphisms, one in the dopamine D2 receptor gene (DRD2) and one in the mu-opioid receptor gene (OPRM1), on the link between parental rule-setting and adolescent alcohol use.
Methods: A total of 214 adolescents (Mage =13.7, 44.9% male) provided saliva samples and completed survey items describing alcohol use and parental rule-setting.
Results: Findings indicated that alcohol-specific parental rule-setting was more robustly associated with alcohol use for adolescents with the DRD2 A1 risk allele and for those with the OPRM1 G-allele. Conclusion: This study replicates the interaction between parental rule-setting and the DRD2 risk allele on adolescent alcohol use and extends the literature by demonstrating the moderating effects of the OPRM1 risk allele on the link between parental rule-setting and adolescent alcohol use.
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