J. de Wit
- B and T cell crosstalk in anti-bacterial immune responses
S.M. van Ham
- Award date
- 4 July 2012
- Number of pages
- Document type
- PhD thesis
- Faculty of Science (FNWI)
- Swammerdam Institute for Life Sciences (SILS)
This thesis shows that phagocytosis of Salmonella by B cells may generate a survival niche and transport vehicle for Salmonella, but that simultaneously Salmonella-infected B cells induce an optimal anti-Salmonella response through activation of multiple arms of the adaptive immune response. The thesis thus forms a clear example of how pathogens and the eukaryotic immune system have coevolved. It enables transient survival of the pathogen within the host, while simultaneously eliciting integrated pathogen-optimized immune responses that eventually clear the pathogen while minimizing host damage.
- Research conducted at: Immunopathologie, Sanquin, Amsterdam
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