- Tick proteins in Borrelia transmission and tick feeding: t(r)ick or treat?
T. van der Poll
A.P. van Dam
- Award date
- 13 October 2011
- Number of pages
- Document type
- PhD thesis
- Faculty of Medicine (AMC-UvA)
The data described in this thesis contribute to the understanding of the role of tick proteins in tick feeding and transmission of Borrelia. Targeting tick proteins that play a crucial role in tick feeding and/or Borrelia transmission are interesting candidates for anti-tick vaccines to prevent Lyme borreliosis. By interfering with the ticks ability to inhibit innate immune responses and activation of coagulation the tick bite site could become a more hostile environment for Borrelia when it enters the skin. Future research is necessary to explore the tick sialome in order to identify and characterize tick proteins to develop a cocktail vaccine that completely blocks pathogen transmission and/or tick feeding. The vaccination approaches discussed in this thesis could be applicable to other vector-borne pathogens as well.
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