- Author
-
P. Saeed
W.R. van Furth
M. Tanck
F. Kooremans
N. Freling
G.J. Streekstra
N.I. Regensburg
J.W. Berkelbach van der Sprenkel
S.M. Peerdeman
J.J. Overbeeke
M.P. Mourits - Year
- 2011
- Title
- Natural history of spheno-orbital meningiomas
- Journal
- Acta neurochirurgica
- Volume | Issue number
- 153 | 2
- Pages (from-to)
- 395-402
- Document type
- Article
- Faculty
- Faculty of Medicine (AMC-UvA)
- Abstract
-
To investigate the natural history and the growth rate of spheno-orbital meningiomas (SOMs). Ninety patients with a diagnosis of SOM were included, and patient charts and imaging were evaluated. In a subset of 32 patients, volumetric studies were performed. The median follow-up for the entire group was 4 years (range, 1-15); the mean age was 47.8 (range, 26-93) years; 94% of the patients were female. The most common clinical signs and symptoms were proptosis (93%), visual deterioration (65%), retro-bulbar pain (23%) and diplopia (6%). In 35% of patients in this series, no visual deterioration occurred, and in 30% only mild proptosis was present. The median annual growth rate of the SOMs in the subset of 32 patients was 0.3 cm³/year (range, 0.03-1.8 cm³/year). We assessed a trend for more rapid tumour growth in younger patients and found the initial volume of the tumour (rho = 0.63) and of the soft tissue component (rho = 074) to be significantly related to the growth rate. SOMs are slow-growing tumours that cause primarily proptosis and visual deterioration. In a significant number of patients, these tumours cause minimal discomfort and symptomatology. Therefore, in the absence of risk factors, we advocate a "wait and see" policy. For patients with large SOMs or with a large soft tissue component at first visit or with fast growing SOMs (>1cm³/year), a follow-up examination every 6 months is indicated
- URL
- go to publisher's site
- Language
- English
- Permalink
- http://hdl.handle.net/11245/1.365032
- Downloads
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