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Author
P. Saeed
W.R. van Furth
M. Tanck
F. Kooremans
N. Freling
G.J. Streekstra
N.I. Regensburg
J.W. Berkelbach van der Sprenkel
S.M. Peerdeman
J.J. Overbeeke
M.P. Mourits
Year
2011
Title
Natural history of spheno-orbital meningiomas
Journal
Acta neurochirurgica
Volume | Issue number
153 | 2
Pages (from-to)
395-402
Document type
Article
Faculty
Faculty of Medicine (AMC-UvA)
Abstract
To investigate the natural history and the growth rate of spheno-orbital meningiomas (SOMs). Ninety patients with a diagnosis of SOM were included, and patient charts and imaging were evaluated. In a subset of 32 patients, volumetric studies were performed. The median follow-up for the entire group was 4 years (range, 1-15); the mean age was 47.8 (range, 26-93) years; 94% of the patients were female. The most common clinical signs and symptoms were proptosis (93%), visual deterioration (65%), retro-bulbar pain (23%) and diplopia (6%). In 35% of patients in this series, no visual deterioration occurred, and in 30% only mild proptosis was present. The median annual growth rate of the SOMs in the subset of 32 patients was 0.3 cm³/year (range, 0.03-1.8 cm³/year). We assessed a trend for more rapid tumour growth in younger patients and found the initial volume of the tumour (rho = 0.63) and of the soft tissue component (rho = 074) to be significantly related to the growth rate. SOMs are slow-growing tumours that cause primarily proptosis and visual deterioration. In a significant number of patients, these tumours cause minimal discomfort and symptomatology. Therefore, in the absence of risk factors, we advocate a "wait and see" policy. For patients with large SOMs or with a large soft tissue component at first visit or with fast growing SOMs (>1cm³/year), a follow-up examination every 6 months is indicated
URL
go to publisher's site
Language
English
Permalink
http://hdl.handle.net/11245/1.365032
Downloads
  • 365032.pdf

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