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Author
M.H. Hazewinkel
L.J.A. Stalpers
M.G. Dijkgraaf
J.P.W.R. Roovers
Year
2011
Title
Prophylactic vesical instillations with 0.2% chondroitin sulfate may reduce symptoms of acute radiation cystitis in patients undergoing radiotherapy for gynecological malignancies
Journal
International Urogynecology Journal
Volume | Issue number
22 | 6
Pages (from-to)
725-730
Document type
Article
Faculty
Faculty of Medicine (AMC-UvA)
Abstract
We studied the feasibility and efficacy of intravesical instillations with 40 ml chondroitin sulfate 0.2% solution to prevent or reduce acute radiation cystitis in women undergoing pelvic radiotherapy. In a comparative pilot study in 20 patients, half of the patients received instillations. Instillations' bother was measured with visual analog scores (VAS, 0-10); bladder pain, with VAS; micturition-related quality of life, with the urogenital distress inventory (UDI). One of the instilled patients discontinued the instillations. The first median "acceptability"-VAS was 0 (range, 0-3); the last median was 1 (range, 0-3). "Bladder pain"-VAS peaked halfway in the treatment among controls (median, 1; range, 0-5) and after treatment in the instilled patients (median, 1; range, 1-3). UDI scores showed over time median follow-up scores at or above median baseline scores in controls and at or below median baseline scores in instilled patients. Intravesical instillations with chondroitin sulfate 0.2% solution may decrease the bother related to bladder symptoms and are well tolerated
URL
go to publisher's site
Language
English
Permalink
http://hdl.handle.net/11245/1.363364
Downloads
  • 363364.pdf

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