- Immunotolerance during bacterial pneumonia and sepsis
T. van der Poll
A.F. de Vos
C. van 't Veer
- Award date
- 29 October 2010
- Number of pages
- Document type
- PhD thesis
- Faculty of Medicine (AMC-UvA)
Bacterial pneumonia and sepsis are a major cause of morbidity and mortality worldwide. Massive use of antibiotics promotes pathogen resistance, and, as a consequence, the incidence of drug-resistant bacteria is increasing. Therefore, it is of the utmost importance to expand our comprehension of host responses against invading pathogens, in order to develop new treatment strategies. This thesis presents experimental studies focused on the immune response against bacteria during (nosocomial) pneumonia and sepsis, and aims to increase our knowledge of the underlying mechanisms of immunotolerance as a feature of patients with sepsis.
- Copyright chapters 2, 4 and 8: American Thoracic Society, reproduced with kind permission. Chapter 2: American Journal of Respiratory and Critical Care Medicine, vol 178. pp. 34-41, 2008, http://dx.doi.org/10.1164/rccm.200708-1261OC. Chapter 4: American Journal of Respiratory Cell and Molecular Biology, vol. 42, pp. 349-356, 2010, http://dx.doi.org/10.1165/rcmb.2008-0362OC. Chapter 8: American Journal of Respiratory and Critical Care Medicine, 2011, http://dx.doi.org/10.1164/rccm.201006-0934OC.
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