- Reduced context effects on retrieval in first-episode schizophrenia
- PLoS One
- Volume | Issue number
- 5 | 4
- Document type
- Faculty of Medicine (AMC-UvA)
Faculty of Social and Behavioural Sciences (FMG)
- Psychology Research Institute (PsyRes)
Background: A recent modeling study by the authors predicted that contextual information is poorly integrated into episodic representations in schizophrenia, and that this is a main cause of the retrieval deficits seen in schizophrenia.
Methodology/Principal Findings: We have tested this prediction in patients with first-episode schizophrenia and matched controls. The benefit from contextual cues in retrieval was strongly reduced in patients. On the other hand, retrieval based on item cues was spared.
Conclusions/Significance: These results suggest that reduced integration of context information into episodic representations is a core deficit in schizophrenia and one of the main causes of episodic memory impairment.
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