Gracilioethers A-C, Antimalarial Metabolites from the Marine Sponge Agelas gracilis

Ueoka, R.; Nakao, Y.; Kawatsu, S.; Yaegashi, J.; Matsumoto, Y.; Matsunaga, S.; Furihata, K; van Soest, R.W.M.; Fusetani, N.

doi:https://doi.org/10.1021/jo900380f

Author: R. Ueoka
Y. Nakao
S. Kawatsu
J. Yaegashi
Y. Matsumoto
S. Matsunaga
K Furihata
R.W.M. van Soest
N. Fusetani
Year: 2009
Title: Gracilioethers A-C, Antimalarial Metabolites from the Marine Sponge Agelas gracilis
Journal: Journal of Organic Chemistry
Volume | Issue number: 74 | 11
Pages (from-to): 4203-4207
Document type: Article
Faculty: Faculty of Science (FNWI)
Abstract: Three new antiprotozoan compounds, gracilioethers A−C (1−3), have been isolated from the marine sponge Agelas gracilis. Their structures were elucidated on the basis of spectroscopic and chemical methods. Gracilioethers A−C showed antimalarial activity against Plasmodium falciparum with IC50 values of 0.5−10 μg/mL, whereas gracilioether B (2) also showed antileishmanial activity.
URL: go to publisher's site
Language: English
Permalink: http://hdl.handle.net/11245/1.333961

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