- Four-dimensional imaging in radiotherapy for lung cancer patients
- Award date
- 20 May 2009
- Number of pages
- Nederlands Kanker Instituut - Antoni van Leeuwenhoek Ziekenhuis
- Document type
- PhD thesis
- Faculty of Medicine (AMC-UvA)
Lung cancer is the most common cause of cancer related death. Overall survival is often poor after treatment with conventional radiotherapy. Improvements may be obtained by increasing the radiation dose; however, this can lead to unacceptable complications of healthy organs in or near the irradiation field. The size of the irradiation field is defined by the size of the tumor plus a treatment margin, to allow for geometrical uncertainties during treatment. The aim of this thesis is to reduce respiration-related geometrical uncertainties by improved imaging, creating patient-specific treatment plans. As a result treatment dose can be increased and/or the risk of complications reduced. For this purpose, four-dimensional imaging acquisition and post-processing techniques were developed and implemented in the clinic.
If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library, or send a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible.