- Brugada syndrome : clinical and pathophysiological aspects
- Award date
- 9 June 2009
- Number of pages
- Document type
- PhD thesis
- Faculty of Medicine (AMC-UvA)
Although impressive progress has been made since the year of recognition of the Brugada syndrome in 1992, many aspects of this intriguing disease remain unknown and are still a matter of international debate. In this thesis, different clinical aspects of the Brugada syndrome are handled, from its diagnosis to the peculiarities of the clinical characteristics in different sub-groups of patients and its therapeutic approach. Particular attention is also given to the genetic background, represented by mutation in the SCN5A gene, encoding the main subunit of the cardiac sodium channel protein.
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