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Author
M.Q. Müller
L.J. de Koning
A. Schmidt
A. Ihling
Y. Syha
O. Rau
K. Mechtler
M. Schubert-Zsilavecz
A. Sinz
Year
2009
Title
An innovative method to study target protein-drug interactions by mass spectrometry
Journal
Journal of Medicinal Chemistry
Volume | Issue number
52 | 9
Pages (from-to)
2875-2879
Document type
Article
Faculty
Faculty of Science (FNWI)
Institute
Swammerdam Institute for Life Sciences (SILS)
Abstract
We report the combination of chemical cross-linking and high-resolution mass spectrometry for analyzing conformational changes in target proteins that are induced by drug binding. With this approach conformational changes in the peroxisome proliferator-activated receptor alpha (PPARα) upon binding of low-molecular weight compounds were readily detected, proving that the strategy provides a basis to efficiently characterize target protein−drug interactions.
URL
go to publisher's site
Language
Undefined/Unknown
Permalink
http://hdl.handle.net/11245/1.313084

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