- Using two-dimensional liquid chromatography to separate complex mixtures of peptides
- LC GC Europe
- Volume | Issue number
- 22 | 5
- Pages (from-to)
- Document type
- Faculty of Science (FNWI)
- Van 't Hoff Institute for Molecular Sciences (HIMS)
Two-dimensional liquid chromatography (2D-LC) allows analysts to deal with complex samples that either cannot be adequately separated by one-dimensional liquid chromatography (1D-LC) or require excessively longanalysis times. Peptide mixtures, whose characterization is relevant in many areas (e.g., proteomics, food analysis, pharmaceutical, life sciences), are a clear example of such complexity. An overview of the most used 2D-LC modes of operation is presented and several examples of their use for the separation of peptide mixtures are described.
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