E.P. de Vink
- In silico modelling and analysis of ribosome kinetics and aa-tRNA competition
- TUCS General Publications
- Pages (from-to)
- Document type
- Faculty of Science (FNWI)
- Swammerdam Institute for Life Sciences (SILS)
We present a formal analysis of ribosome kinetics using probabilistic model checking and the tool Prism. We compute different parameters of the model, like probabilities of translation errors and average insertion times per codon. The model predicts strong correlation to the quotient of the concentrations of the so-called cognate and near-cognate tRNAs, in accord with experimental findings and other studies. Using piecewise analysis of the model, we are able to give an analytical explanation of this observation.
- Proceedings title: Proceedings of COMPMOD 2008: Workshop on Computational Models for Cell Processes
Publisher: Turku Centre for Computer Science (TUCS)
Place of publication: Turku
Editors: R.-J. Back, I. Petre
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