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Author
W.A. van der Reijden
C.J. Bosch-Tijhof
U. van der Velden
A.J. van Winkelhoff
Year
2008
Title
Java project on periodontal diseases: serotype distribution of Aggregatibacter actinomycetemcomitans and serotype dynamics over an 8-year period
Journal
Journal of Clinical Periodontology
Volume | Issue number
35 | 6
Pages (from-to)
487-492
Number of pages
6
Document type
Article
Faculty
Faculty of Dentistry (ACTA)
Abstract
Objective: To investigate the serotype distribution and stability of Aggregatibacter
actinomycetemcomitans over an 8-year period in untreated Indonesian subjects.
Material and Methods: Clinical periodontal status and the presence of
A. actinomycetemcomitans were established in 1994 and 2002 in 107 subjects from
an Indonesian tea estate deprived from dental care. On an average, 3.6 isolates per
patient were subcultured and serotyped using specific PCR reactions.
Results: In 1994, the predominant serotype was b (53.7%), whereas a and c occurred
in 17.1% and 14.6% of the subjects, respectively. In 2002, a reduction in serotypes a
(7.5%) and b (30.2%) occurred. Serotypes c and e increased in prevalence from 14.6%
to 35.8% and 2.4% to 9.4%, respectively. Multiple serotypes were found in 12.2%
in 1994 and 17% in 2002. From 24 subjects who were positive at both time points,
14 (58.3%) had the same serotype, whereas in 10 subjects (41.7%), a different serotype
was found. Mean clinical attachment loss had increased from 0.74mm in 1994 to
1.96mm in 2002 but could not be related to subgingival presence of A. actinomycetemcomitans.
Conclusions: A. actinomycetemcomitans serotypes distribution in Indonesian young
adults shifts from predominantly serotype b to a more equal prevalence of serotypes b
and c. This shift suggests an opportunistic character of A. actinomycetemcomitans.
URL
go to publisher's site
Language
Undefined/Unknown
Permalink
http://hdl.handle.net/11245/1.292388

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