- Simulating complex calcium-calcineurin signaling network
- Lecture Notes in Computer Science
- Pages (from-to)
- Document type
- Faculty of Science (FNWI)
- Informatics Institute (IVI)
Understanding of processes in which calcium signaling is involved is of fundamental importance in systems biology and has many applications in medicine. In this paper we have studied the particular case of the complex calcium-calcineurin-MCIP-NFAT signaling network in cardiac myocytes, the understanding of which is critical for treatment of pathologic hypertrophy and heart failure. By including some most recent experimental findings, we constructed a computational model totally based on biochemical principles. The model can correctly predict the mutant (MCIP1-/-) behavior under different stress such as PO (pressure overload) and CaN* (activated calcineurin) overexpression.
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- Proceedings title: Computational science - ICCS 2008: 8th international conference, Kraków, Poland, June 23-25, 2008: Proceedings:
Place of publication: Berlin
Editors: M. Bubak, G.D. van Albada, J. Dongarra, P.M.A. Sloot
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