- Studies on puupehenone-metabolites of a Dysidea sp.: structure and biological activity
- Number of pages
- Document type
- Faculty of Science (FNWI)
- Abstract—Puupehenone (1) and a series of its congeners (2-6) have been isolated from a Dysidea sponge. The unprecedented 20-acetoxyhaterumadienone
(2) exhibiting a five-membered contracted ring, has been characterized. In addition, stereochemical assignment of two previously
reported acetone adducts of puupehenone (5 and 6) has been made. Finally, the inhibition of mitochondrial respiratory chain
as well as antibacterial and antifungal activities of all compounds has been evaluated.
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