- Limited regression of central giant cell granuloma by interferon alpha after failed calcitonin therapy: a report of 2 cases
- International Journal of Oral and Maxillofacial Surgery
- Volume | Issue number
- 35 | 9
- Pages (from-to)
- Document type
- Faculty of Dentistry (ACTA)
Faculty of Medicine (AMC-UvA)
Central giant cell granuloma (CGCG) is a benign lesion of the jaws with a sometimes locally aggressive behaviour. The most common therapy is surgical curettage which has a high recurrence rate, especially in lesions with aggressive signs and symptoms (i.e. pain, paresthesia, root-resorption and rapid growth). Alternative therapies such as interferon alpha (INFα) or calcitonin are described in the literature. In this study 2 patients with an aggressive CGCG are presented who were treated with INF mono-therapy.
INF mono-therapy was capable of terminating the rapid growth of the lesion in both patients and induced a partial reduction. Total resolution, however, was not obtained and alternative treatment is still necessary.
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