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Author
P.J.P. Chameau
J.A. van Hooft
Year
2006
Title
Serotonin 5-HT(3) receptors in the central nervous system
Journal
Cell and Tissue Research
Volume
326
Pages (from-to)
573-581
Document type
Article
Faculty
Faculty of Science (FNWI)
Institute
Swammerdam Institute for Life Sciences (SILS)
Abstract
The 5-HT(3) receptor is a ligand-gated ion channel activated by serotonin (5-HT). Although originally identified in the peripheral nervous system, the 5-HT(3) receptor is also ubiquitously expressed in the central nervous system. Sites of expression include several brain stem nuclei and higher cortical areas such as the amygdala, hippocampus, and cortex. On the subcellular level, both presynaptic and postsynaptic 5-HT(3) receptors can be found. Presynaptic 5-HT(3) receptors are involved in mediating or modulating neurotransmitter release. Postsynaptic 5-HT(3) receptors are preferentially expressed on interneurons. In view of this specific expression pattern and of the well-established role of 5-HT as a neurotransmitter shaping development, we speculate that 5-HT(3) receptors play a role in the formation and function of cortical circuits
URL
go to publisher's site
Language
Undefined/Unknown
Permalink
http://hdl.handle.net/11245/1.258722

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