Novel anticoagulant and prohemostatic strategies

Friederich, P.W.

Author: P.W. Friederich
Title: Novel anticoagulant and prohemostatic strategies
Supervisors: M.M. Levi
H.R. Büller
Co-supervisors: B.J. Biemond
Award date: 12 September 2000
Number of pages: 225
ISBN: 9090139788
9789090139784
Document type: PhD thesis
Faculty: Faculty of Medicine (AMC-UvA)
Note: Research conducted at: CRIA
Permalink: http://hdl.handle.net/11245/1.172908

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Thesis
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Contents
CHAPTER 1 GENERAL INTRODUCTION
CHAPTER 2 COMPARISON OF SUSTAINED ANTITHROMBOTIC EFFECTS OF INHIBITORS OF THROMBIN AND FACTOR Xa IN EXPERIMENTAL THROMBOSIS
CHAPTER 3 SUCCESSFUL ATTENUATION OF VENOUS THROMBUS GROWTH IN RABBITS AFTER THE ADMINISTRATION OF A NOVEL ORAL THROMBIN INHIBITOR
CHAPTER 4 A NOVEL DIRECT SPECIFIC THROMBIN INHIBITOR (S 18326) ATTENUATES THROMBUS GROWTH AND ENHANCES THROMBOLYSIS IN A RABBIT VENOUS THROMBOSIS MODEL
CHAPTER 5 A NOVEL LOW MOLECULAR WEIGHT INHIBITOR OF PAI-1 (XR5118) REDUCES POST-THROMBOLYSIS THROMBUS GROWTH AND PROMOTES ENDOGENOUS FIBRINOLYSIS IN RABBITS
CHAPTER 6 APOLIPOPROTEIN(A) ATTENUATES ENDOGENOUS FIBRINOLYSIS IN THE RABBIT JUGULAR VEIN THROMBOSIS MODEL IN VIVO
CHAPTER 7 ENHANCEMENT OF RABBIT JUGULAR VEIN THROMBOLYSIS BY NEUTRALIZATION OF FACTOR XI: IN VIVO EVIDENCE FOR A ROLE OF FACTOR XI AS AN ANTI-FIBRINOLYTIC FACTOR
CHAPTER 8 FIBRINOGEN-COATED ALBUMIN MICROCAPSULES REDUCE BLEEDING IN SEVERELY THROMBOCYTOPENIC RABBITS.
CHAPTER 9 THE ABILITY OF RECOMBINANT FACTOR VIIa TO GENERATE THROMBIN DURING INHIBITION OF THE TISSUE FACTOR/FACTOR VIIa COMPLEX IN HUMAN SUBJECTS
CHAPTER 10 ACTIVATION OF COAGULATION BY ADMINISTRATION OF RECOMBINANT FACTOR VIIA ELICITS INTERLEUKIN (IL)-6 AND IL-8 RELEASE IN HEALTHY HUMAN SUBJECTS
CHAPTER 11 RECOMBINANT ACTIVATED FACTOR VII: A UNIVERSAL HEMOSTATIC AGENT?
CHAPTER 12 REDUCTION OF PERIOPERATIVE BLOOD LOSS AND TRANSFUSION REQUIREMENT IN PATIENTS UNDERGOING TRANSABDOMINAL RETROPUBIC PROSTATECTOMY BY ADMINISTRATION OF RECOMBINANT ACTIVATED FACTOR VII
CHAPTER 13 SUCCESSFUL TREATMENT WITH RECOMBINANT FACTOR VIIA OF THERAPY-RESISTANT SEVERE BLEEDING IN A PATIENT WITH ACQUIRED VON WILLEBRAND DISEASE
Co-authors
Samenvatting
Dankwoord
Curriculum Vitae
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