- Brain, nutrition and metabolism
- Studies in lean, obese and insulin resistant humans
S.E. la Fleur
- Award date
- 26 April 2017
- Number of pages
- Document type
- PhD thesis
- Faculty of Medicine (AMC-UvA)
This thesis describes studies on the effects of obesity, weight loss and meal timing on the human brain and glucose metabolism. We investigated effects of meal timing during a hypocaloric diet and weight loss on brain serotonin transporters (SERT) and dopamine transporters (DAT), neuronal activity patterns and metabolism. In addition, we studied the effect of bright light conditions on glucose and lipid metabolism in lean and obese subjects with type 2 diabetes (T2D). First, we show a trend towards lower hypothalamic SERT binding in obese compared to lean controls and a reduced SERT binding in the diencephalon in obese insulin resistant compared to equally obese insulin sensitive and lean subjects. Second, we show that subjects who consumed most of the calories in the morning during a hypocaloric diet, increased striatal DAT binding and reduced neuronal activation in response to high calorie food pictures in the caudate nucleus, while consuming most of the calories in the evening reduced striatal DAT binding and increased neuronal activation in response to high calorie food pictures in the caudate nucleus. Metabolism and intrahepatic triglyceride content improved after weight loss but without a differential effect of meal timing. Finally, we found that acute exposure to bright light affects glucose metabolism in obese subjects with T2D and lipid metabolism in both, patients with T2D and healthy controls. Taken together, this thesis provides data supporting a clinically relevant interaction between meal timing, body weight loss and the brain, and between light exposure and metabolism.
- Please note that the sections 'Dankwoord' and 'Curriculum Vitae' (pp. 234-239) are not included in the thesis downloads.
Thesis (Embargo up to and including 26 April 2019)
Chapter 4: Timing of caloric intake during weight loss differentially affects striatal dopamine transporter and thalamic serotonin transporter binding in obese men (Embargo up to and including 26 April 2018)
Chapter 5: Meal timing during weight loss differentially affects brain responses to visual food cues in the caudate nucleus of obese men (Embargo up to and including 26 April 2018)
Chapter 6: Weight loss improves insulin sensitivity and decreases intrahepatic triglycerides independent of meal timing (Embargo up to and including 26 April 2019)
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