J. van Duynhoven
- Quantification of lipoprotein profiles by nuclear magnetic resonance spectroscopy and multivariate data analysis
- Trends in Analytical Chemistry
- Pages (from-to)
- Document type
- Faculty of Science (FNWI)
- Swammerdam Institute for Life Sciences (SILS)
Lipoproteins and their subfraction profiles have been associated to diverse diseases including Cardio Vascular Disease (CVD). There is thus a great demand for measuring and quantifying the lipoprotein profile in an efficient and accurate manner.
Nuclear Magnetic Resonance (NMR) spectroscopy is uniquely able to measure the lipoprotein profile of a blood sample non-destructively due to its sensitivity to both lipid chemistry and lipid-micellar physics.
However, the NMR spectra must be scaled/regressed to a primary method of reference, such as ultracentrifugation, using multivariate regression methods.
This review provides an overview of the field and explains the methods at stake.
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