- A single nucleotide change in the promoter mutp enhances fluoride resistance of Streptococcus mutans
- Antimicrobial Agents and Chemotherapy
- Volume | Issue number
- 60 | 12
- Pages (from-to)
- Document type
- Faculty of Dentistry (ACTA)
Previously, we identified a single nucleotide mutation in the promoter (mutp) of the fluoride antiporter-coding genes in a naturally fluoride-resistant Streptococcus mutans strain. Here, we studied the role of this mutation in a defined genetic background. The results confirmed that this mutation alone confers fluoride resistance on S. mutans, as shown by growth and lactic acid production assays. This resistance was explained by constitutively higher mutp promoter activity and upregulation of the fluoride antiporter-coding genes.
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- © 2016, American Society for Microbiology. - With supplemental material.
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