- Untangling pathways between childhood trauma and psychosis
L. de Haan
- Award date
- 17 February 2017
- Number of pages
- Document type
- PhD thesis
- Faculty of Medicine (AMC-UvA)
The studies presented in this thesis aim to enhance our knowledge with regard to specific associations between types of trauma and the course of symptomatology and psychosocial functioning and to examine possible underlying mechanisms, by which childhood trauma influences the development of psychosis.
Chapter 2 addresses whether being bullied in childhood is related to the development of psychotic symptoms in non-clinical and clinical samples.
In chapter 3 the specificity of type of abuse and neglect in relation to different symptom domains of psychosis is discussed.
Chapter 3 and 4 explore whether abuse and neglect uniquely heighten the chance of developing psychotic symptomatology in persons who are genetically vulnerable to developing psychotic symptoms. The association between abuse and neglect and course of symptoms over time of psychotic symptoms was evaluated, both in patients and in individuals with psychotic symptoms. Chapter 4 also addresses the question whether childhood abuse and neglect are predictive for transition to psychosis.
Chapter 5.1 and 5.2 address the association between childhood trauma and cognitive functioning in psychosis.
Chapter 6 examines whether childhood trauma - considering both type I and type II childhood trauma and childhood bullying - is associated with smaller hippocampal and amygdala volume in patients with psychosis.
In chapter 7 the hypothesis that adult attachment is a mediating mechanism between childhood trauma and the development of psychosis is tested.
Chapter 8 addresses the question whether personality characteristics are related to psychosocial functioning in patients with psychosis and a history of childhood trauma.
In chapter 9 a summary of the previous chapters is presented, along with a general discussion of the implications, limitations and suggestions for future research.
Thesis (complete) (Embargo until 17 February 2019)
Chapter 4: Childhood trauma and clinical outcome in patients at ultra-high risk of transition of psychosis (Embargo until 17 February 2019)
Chapter 5.1: Change in IQ during the first years of schizophrenia: a controlled longitudinal study (Embargo until 17 February 2019)
Chapter 5.2: Evidence that the impact of childhood trauma on IQ is substantial in controls, moderate in siblings and absent in patients with psychotic disorder (Embargo until 17 February 2019)
Chapter 6: Childhood trauma in patients with psychotic disorders is associated with hippocampal volume: a sMRI study (Embargo until 17 February 2019)
Chapter 7: Childhood maltreatment, adult attachment and psychotic symptomatology: a study in patients, siblings and controls (Embargo until 17 February 2019)
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