- Catalytic Enantioselective Addition of Organozirconium Reagents to Aldehydes
- Volume | Issue number
- 23 | 4
- Article number
- Number of pages
- Document type
- Faculty of Science (FNWI)
- Van 't Hoff Institute for Molecular Sciences (HIMS)
A catalytic enantioselective addition reaction of alkylzirconium species to aromatic
aldehydes is reported. The reaction, facilitated by a chiral nonracemic diol ligand complex with
Ti(OiPr)4, proceeds under mild and convenient conditions, and no premade organometallic reagents
are required since the alkylzirconium nucleophiles are generated in situ by hydrozirconation of
alkenes with the Schwartz reagent. The methodology is compatible with functionalized nucleophiles
and a broad range of aromatic aldehydes.
- go to publisher's site
- In special issue "Stereogenic Centers". With supporting information.
If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library, or send a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible.