- Diagnosis and treatment of common infectious diseases in severely ill sub-Saharan African patients
- Studies from a hospital floor
R.M. van Hest
- Award date
- 8 September 2017
- Number of pages
- Document type
- PhD thesis
- Faculty of Medicine (AMC-UvA)
This thesis illustrates that important aspects of diagnosis and treatment of common infectious diseases in a hospital setting in Mozambique are inadequate. The inadequacies found in our studies are likely to be explained by a combination of patient population factors and health care system restraints. Although substantial differences may exist between hospitals and between countries, studies from other sub-Saharan Africa low-income countries with colliding HIV and TB epidemics have shown that the sort of inadequacies we observed are neither unique to one hospital, nor to one country. The study results and the underlying issues raised provide starting points for change and ideas for further research.
Thesis (complete) (Embargo up to and including 08 September 2018)
Chapter 4: Pharmacokinetics of antibiotics in sub-Saharan African patient populations: a systematic review (Embargo up to and including 08 March 2018)
Chapter 5: Pharmacokinetics and pharmacodynamic target attainment of ceftriaxone in an adult severely ill sub-Saharan African hospital population (Embargo up to and including 08 September 2018)
Chapter 6: Pharmacokinetics and pharmacodynamic target attainment of benzylpenicillin in an adult severely ill sub-Saharan African hospital population (Embargo up to and including 08 September 2018)
Chapter 7: Paracetamol clinical dosing routine leads to paracetamol underexposure in an adult severely ill sub-Saharan African hospital population: a drug concentration measurement study (Embargo up to and including 08 September 2018)
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