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| Authors | M. van Luin, M.E. van der Ende, C.J.J. Richter, M. Visser, D. Faraj, A. van der Ven, L. Gelinck, F. Kroon, F.W. Wit, R.H. van Schaik, P.F. Kuks, D.M. Burger | | Title | Lower atovaquone/proguanil concentrations in patients taking efavirenz, lopinavir/ritonavir or atazanavir/ritonavir |
| Journal | AIDS |
| Volume | 24 |
| Year | 2010 |
| Issue | 8 |
| Pages | 1223-1226 |
| ISSN | 02699370 |
| Faculty | AMC-UvA |
| Abstract | HIV-infected travellers frequently use atovaquone/ proguanil as malaria prophylaxis. We compared atovaquone/ proguanil pharmacokinetics between healthy volunteers and HIV-infected patients taking efavirenz, lopinavir/ ritonavir or atazanavir/ritonavir. The geometric mean ratio (95% confidence interval) area under the curve (AUC)(0 -> t) for atovaquone relative to the healthy volunteers was 0.25 (0.16-0.38), 0.26 (0.17-0.41) and 0.54 (0.350.83) for patients on efavirenz, lopinavir/ ritonavir and atazanavir/ ritonavir, respectively. Proguanil plasma concentrations were also significantly lower (38-43%). Physicians should be alert for atovaquone/ proguanil prophylaxis failures in patients taking efavirenz, lopinavir/ ritonavir or atazanavir/ ritonavir |
| Document type | Article |
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