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Record: oai:ARNO:391041

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Author M.E. Visser Title Dyslipidemia, sense, antisense or nonsense? Promotor E.S.G. Stroes Co-promotor G.M. Dallinga-Thie Date 07-09-2011 Year 2011 Pages 194 ISBN 9789461081940 Faculty AMC-UvA Abstract Maartje Visser onderzocht het remmen van de synthese van apoB met behulp van antisense - een nieuwe farmacologische techniek. Dit blijkt het slechte LDL-cholesterol op een effectieve manier te verlagen. Bij sommige proefpersonen resulteerde dit in leververvetting. Of dit op de lange termijn schadelijk is, moet verder worden onderzocht. Bij patiënten met een natuurlijk verlaagd apoB lijkt leververvetting in elk geval niet schadelijk. Language English Document type Dissertation Download papers Thesis   Cover Title pages Table of contents Chapter 1: General introduction and outline of this thesis Chapter 2: Apolipoprotein B synthesis inhibition: results from clinical trials Chapter 3: Effect of mipomersen, an apolipoprotein B synthesis inhibitor, on low-density lipoprotein cholesterol in patients with familial hypercholesterolemia Chapter 4: Effect of apolipoprotein B synthesis inhibition on liver triglyceride content in patients with familial hypercholesterolemia Chapter 5: Mipomersen, an apolipoprotein B synthesis inhibitor, lowers LDL cholesterol in high risk-statin intolerant patients: a randomized, double-blind placebo controlled trial Chapter 6: Hepatic steatosis does not cause insulin resistance in people with familial hypobetalipoproteinemia Chapter 7: Characterization of non-obese diabetic patients with marked insulin resistance identifies a novel familial partial lipodystrophy-associated PPARg mutation (Y151C) Chapter 8: Metabolic dyslipidemia and risk of future coronary heart disease in apparently healthy men and women: the EPICNorfolk prospective population study Chapter 9: Mutations in LPL, APOC2, APOA5, GPIHBP1 and LMF1 in patients with severe hypertriglyceridemia Chapter 10: Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia Chapter 11: Summary, discussion and future perspectives Chapter 12: Nederlandse samenvatting Dankwoord Stellingen Document finder Use this url to link to this page: http://dare.uva.nl/en/record/391041 Contact us about this recordNotify a colleague Add to bookbag

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