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| Authors | J.C.J. Calis, K.S. Phiri, R.J.W.M. Vet, R.J. de Haan, F. Munthali, R.J. Kraaijenhagen, P.J.M. Hulshof, M.E. Molyneux, B.J. Brabin, M. Boele van Hensbroek, I. Bates | | Title | Erythropoiesis in HIV-infected and uninfected Malawian children with severe anemia |
| Journal | AIDS |
| Volume | 24 |
| Year | 2010 |
| Issue | 18 |
| Pages | 2883-2887 |
| ISSN | 02699370 |
| Faculty | AMC-UvA |
| Abstract | Anemia is common in HIV infection, but the pathophysiology is poorly understood. Bone marrow analysis in 329 severely anemic (hemoglobin <5 g/dl) Malawian children with (n = 40) and without (n = 289) HIV infection showed that HIV-infected children had fewer CD34(+) hematopoietic progenitors (median 10 vs. 15‰, P = 0.04) and erythroid progenitors (2.2 vs. 3.4‰, P = 0.05), but there were no differences in erythrocyte viability and maturation in later stages of erythropoiesis. Despite an HIV-associated reduction in early red cell precursors, subsequent erythropoiesis appears to proceed similarly in HIV-infected and HIV-uninfected children with severe anemia |
| Document type | Article |
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