The UvA-LINKER will give you a range of other options to find the full text of a publication (including a direct link to the full-text if it is located on another database on the internet).
De UvA-LINKER biedt mogelijkheden om een publicatie elders te vinden (inclusief een directe link naar de publicatie online als deze beschikbaar is in een database op het internet).

Search results

Record: oai:ARNO:381216

AuthorsJ. Raaphorst, H.F. Grupstra, W.H.J.P. Linssen, J.C. van Swieten, B. Schmand, M. de Visser
TitleAmyotrofische laterale sclerose en frontotemporale dementie: overlap in kenmerken
JournalNederlands Tijdschrift voor Geneeskunde
Volume154
Year2010
IssueA631
ISSN00282162
FacultyFaculty of Social and Behavioural Sciences
AMC-UvA
Institute/dept.FMG: Psychology Research Institute
AbstractThere is an overlap between amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Some 5-10% of ALS patients show changes in their behaviour and personality that are characteristic of FTD and about 10% of FTD patients develop ALS. Mild cognitive impairment occurs in 30% of ALS patients. The progressive decline of muscle strength in ALS patients and social skills in FTD patients places severe demands on the patient and his or her contacts. In some ALS and FTD patients, ubiquitin-positive inclusions have been found in the hippocampus and anterior horn cells. In patients with familial FTD who have ubiquitin-positive inclusions, mutations have been found in the progranulin (PGRN) gene. TAR-DNA-binding protein-43, encoded by the TARDBP gene, has recently been identified as a constituent of the ubiquitin inclusions. TARDBP and PGRN mutations are found in patients with ALS. The overlapping characteristics provide clues for further research into the pathogenesis of ALS and FTD
Document typeArticle
Document finderUvA-Linker